YongXiang Chen's Research Group
We seek to develop powerful chemistry-driven toolkits for generating specifically modified proteins and peptides bearing magic natural or artificial chemical moieties, which benefit the mechanistic investigation and biomedical application.
Our group is very interdisciplinary. Welcome the graduate and undergraduate students who are enthusiastic about protein chemistry and biology to join us!
Research Directions
Our group focuses on three main research topics in protein chemistry and biology.
Modified Proteins for Mechanistic Investigation
Developing efficient synthetic strategies for accessing pathological modified proteins by combining chemical and biological synthesis techniques.
Protein Phosphine Ligand for Metalloprotein Design
Developing bio-synthetic tools for accessing specifically phosphine-modified proteins for rational design of novel artificial metalloenzymes.
Bio-interfaces for Biomedical Purpose
Developing effective strategies for suppressing activities of K-Ras and Tau proteins, and biocompatible proteins for bio-interface modulation.
Recent Publications
Selected publications from our research group.
Customized synthesis of phosphoprotein bearing phosphoserine or its nonhydrolyzable analog.
Synthetic and Systems Biotechnology, 8(1), 69-78
Genetically Encoded Phosphine Ligand for Metalloprotein Design.
Journal of the American Chemical Society, 144(50), 22831-22837
Intrinsically Disordered Protein Condensate-Modified Surface for Mitigation of Biofouling and Foreign Body Response.
Journal of the American Chemical Society, 144(27), 12147-12157