Publications

Selected publications from our research group (since 2016, as corresponding author *)

2023

1

Customized synthesis of phosphoprotein bearing phosphoserine or its nonhydrolyzable analog.

Liu Dong^#, Liu Yingying^#, Duan Hua-Zhen, Chen Xinjie, Wang Yanan, Wang Ting, Yu Qing, Chen Yong-Xiang^*, & Lu Yuan^#.

Synthetic and Systems Biotechnology, 2023, 8(1), 69-78

DOI: 10.1016/j.synbio.2022.11.004

2022

2

Genetically Encoded Phosphine Ligand for Metalloprotein Design.

Duan Hua-Zhen^#, Hu Cheng^#, Li Yue-Lin, Wang Shi-Hao, Xia Yan, Liu Xiaohong^*, Wang Jiangyun^*, & Chen Yong-Xiang^*.

Journal of the American Chemical Society, 2022, 144(50), 22831-22837

DOI: 10.1021/jacs.2c09683

3

Intrinsically Disordered Protein Condensate-Modified Surface for Mitigation of Biofouling and Foreign Body Response.

Chang Rong, Chen Jia-Lin, Zhang Guan-Yi, Li Yue, Duan Hua-Zhen, Luo Shi-Zhong^*, & Chen Yong-Xiang^*.

Journal of the American Chemical Society, 2022, 144(27), 12147-12157

DOI: 10.1021/jacs.2c02677

4

Phosphorylated and Phosphonated Low-Complexity Protein Segments for Biomimetic Mineralization and Repair of Tooth Enamel.

Chang Rong^#, Liu Yang-Jia^#, Zhang Yun-Lai, Zhang Shi-Ying, Han Bei-Bei, Chen Feng^*, & Chen Yong-Xiang^*.

Advanced Science, 2022, 2103829

DOI: 10.1002/advs.202103829

5

CASTING: A Potent Supramolecular Strategy to Cytosolically Deliver STING Agonist for Cancer Immunotherapy and SARS-CoV-2 Vaccination.

Wu Jun-Jun^#, Chen Fang-Yuan^#, Han Bei-Bei^#, Zhang Hong-Qing^#, et al., Zhang Bo^*, Chen Yong-Xiang^*, Guo Dong-Sheng^*, & Li Yan-Mei^*.

CCS Chemistry, 2022

DOI: 10.31635/ccschem.022.202201859

6

Recent Advances in Post-polymerization Modifications on Polypeptides: Synthesis and Applications.

Li Yue, Chang Rong, & Chen Yong-Xiang^*.

Chemistry - An Asian Journal, 2022, 17, e202200318

DOI: 10.1002/asia.202200318

2021

7

Different phosphorylation and farnesylation patterns tune Rnd3-14-3-3 interaction in distinct mechanisms.

Hu Jun, Sun Xue-Meng, Su Jing-Yun, Zhao Yu-Fen, & Chen Yong-Xiang^*.

Chemical Science, 2021, 12(12), 4432-4442

DOI: 10.1039/d0sc05838f

8

Facile Synthesis of Boc-Protected Selenocystine and its Compatibility with Late-Stage Farnesylation at Cysteine Site.

Zhu Peng-Cheng, & Chen Yong-Xiang^*.

Protein and Peptide Letters, 2021, 28(6), 603-611

DOI: 10.2174/0929866527666201223094249

2020

9

Inhibition of K-Ras4B-plasma membrane association with a membrane microdomain-targeting peptide.

Li Fang-Yi, Zhang Zhen-Feng, Voss Stephanie, Wu Yao-Wen, Zhao Yu-Fen, Li Yan-Mei, & Chen Yong-Xiang^*.

Chemical Science, 2020, 11(3), 826-832

DOI: 10.1039/c9sc04726c

10

Unremitting progresses for phosphoprotein synthesis.

Duan Hua-Zhen, Nie Zhen-Ke, Li Yue, & Chen Yong-Xiang^*.

Current Opinion in Chemical Biology, 2020, 58, 96-111

DOI: 10.1016/j.cbpa.2020.07.009

11

Modern Peptide and Protein Chemistry: Reaching New Heights.

Hackenberger Christian P. R.^*, Dawson Philip E.^*, Chen Yong-Xiang^*, & Hojo Hironobu^*.

Journal of Organic Chemistry, 2020, 85(3), 1328-1330 [Editorial]

DOI: 10.1021/acs.joc.0c00104

12

A host-guest ATP responsive strategy for intracellular delivery of phosphopeptides.

Han Bei-Bei^#, Pan Yu-Chen^#, Li Yan-Mei, Guo Dong-Sheng^*, & Chen Yong-Xiang^*.

Chemical Communications, 2020, 56(41), 5512-5515

DOI: 10.1039/d0cc01800g

13

Metal ion and light sequentially induced sol-gel-sol transition of a responsive peptide-hydrogel.

Zhang Yun-Lai, Chang Rong, Duan Hua-Zhen, & Chen Yong-Xiang^*.

Soft Matter, 2020, 16(33), 7652-7658

DOI: 10.1039/d0sm00442a

2019

14

Stereoselective synthesis of a phosphonate pThr mimetic via palladium-catalyzed gamma-C(sp3)-H activation for peptide preparation.

Duan Hua-Zhen, Chen Hong-Xue, Yu Qing, Hu Jun, Li Yan-Mei, & Chen Yong-Xiang^*.

Organic & Biomolecular Chemistry, 2019, 17(8), 2099-2102

DOI: 10.1039/c8ob02999g

15

TDP-43 specific reduction induced by Di-hydrophobic tags conjugated peptides.

Gao Na, Huang Yun-Peng, Chu Ting-Ting, Li Qian-Qian, Zhou Bing, Chen Yong-Xiang^*, Zhao Yu-Fen, & Li Yan-Mei^*.

Bioorganic Chemistry, 2019, 84, 254-259

DOI: 10.1016/j.bioorg.2018.11.042

2018

16

Synthesis of alpha,alpha-Difluorinated Phosphonate pSer/pThr Mimetics via Rhodium-Catalyzed Asymmetric Hydrogenation.

Chen Hong-Xue^#, Kang Jie^#, Chang Rong, Zhang Yun-Lai, Duan Hua-Zhen, Li Yan-Mei, & Chen Yong-Xiang^*.

Organic Letters, 2018, 20(11), 3278-3281

DOI: 10.1021/acs.orglett.8b01151

17

A site-specific branching poly-glutamate tag mediates intracellular protein delivery by cationic lipids.

Huang Si-Qi, Han Bei-Bei, Li Yan-Mei, & Chen Yong-Xiang^*.

Biochemical and Biophysical Research Communications, 2018, 503(2), 671-676

DOI: 10.1016/j.bbrc.2018.06.059

18

Synthesis of Ras proteins and their application in biofunctional studies.

Hu Jun^#, Zhu Pengcheng^#, Li Yanmei, & Chen Yong-Xiang^*.

Chinese Chemical Letters, 2018, 29(7), 1043-1050

DOI: 10.1016/j.cclet.2018.05.035

19

Inward Budding and Endocytosis of Membranes Regulated by de Novo Designed Peptides.

Yu Qiuhong, Sun Jianbo, Huang Siqi, Chang Haojing, Bai Qingwen, Chen Yong-Xiang^*, & Liang Dehai^*.

Langmuir, 2018, 34(21), 6183-6193

DOI: 10.1021/acs.langmuir.8b00882

2017

20

Phosphorylation Weakens but Does Not Inhibit Membrane Binding and Clustering of K-Ras4B.

Zhang Si-Yu, Sperlich Benjamin, Li Fang-Yi, et al., Winter Roland^*, & Chen Yong-Xiang^*.

ACS Chemical Biology, 2017, 12(6), 1703-1710

DOI: 10.1021/acschembio.7b00165

21

Facile synthesis of Fmoc-protected phosphonate pSer mimetic and its application in assembling a substrate peptide of 14-3-3 zeta.

Kang Jie^#, Chen Hong-Xue^#, et al., & Chen Yong-Xiang^*.

Tetrahedron Letters, 2017, 58(26), 2551-2553

DOI: 10.1016/j.tetlet.2017.05.037

22

Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau.

Gao Na, Chu Ting-Ting, et al., Chen Yong-Xiang^*, Zhao Yu-Fen, & Li Yan-Mei^*.

RSC Advances, 2017, 7(64), 40362-40366

DOI: 10.1039/c7ra05347a

23

Semi-synthesis of murine prion protein by native chemical ligation and chemical activation for preparation of polypeptide-thioester.

Shi Lei, Chen Huai, Zhang Si-Yu, et al., Chen Yong-Xiang^*, & Li Yan-Mei^*.

Journal of Peptide Science, 2017, 23(6), 438-444

DOI: 10.1002/psc.3008

2016

24

Specific Knockdown of Endogenous Tau Protein by Peptide-Directed Ubiquitin-Proteasome Degradation.

Chu Ting-Ting, Gao Na, Li Qian-Qian, Chen Pu-Guang, Yang Xi-Fei, Chen Yong-Xiang^*, Zhao Yu-Fen, & Li Yan-Mei.

Cell Chemical Biology, 2016, 23(4), 453-461

DOI: 10.1016/j.chembiol.2016.02.016

25

Dual-labeling of ubiquitin proteins by chemoselective reactions for sensing UCH-L3.

Li Lei, Zhang Si-Yu, Li Yan-Mei, & Chen Yong-Xiang^*.

Molecular Biosystems, 2016, 12(6), 1764-1767

DOI: 10.1039/c6mb00165c

26

Phosphorylation regulates proteolytic efficiency of TEV protease detected by a 5(6)-carboxyfluorescein-pyrene based fluorescent sensor.

He Yao-Hui, Li Yan-Mei, & Chen Yong-Xiang^*.

Talanta, 2016, 150, 340-345

DOI: 10.1016/j.talanta.2015.12.028